Macrophage stimulating protein may promote tubular regeneration after acute injury.

نویسندگان

  • Vincenzo Cantaluppi
  • Luigi Biancone
  • Giuseppe Mauriello Romanazzi
  • Federico Figliolini
  • Silvia Beltramo
  • Francesco Galimi
  • Maria Gavina Camboni
  • Elisa Deriu
  • Piergiulio Conaldi
  • Antonella Bottelli
  • Viviana Orlandi
  • Maria Beatriz Herrera
  • Alfonso Pacitti
  • Giuseppe Paolo Segoloni
  • Giovanni Camussi
چکیده

Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after transplantation. In addition, MSP and its receptor, RON, were markedly upregulated in the regenerative phase after glycerol-induced tubular injury in mice. In vitro, MSP stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating Fas, mitochondrial proteins, Akt, and extracellular signal-regulated kinase. MSP also enhanced migration, scattering, branching morphogenesis, tubulogenesis, and mesenchymal de-differentiation of surviving tubular cells. In addition, MSP induced an embryonic phenotype characterized by Pax-2 expression. In conclusion, MSP is upregulated during the regeneration of injured tubular cells, and it exerts multiple biologic effects that may aid recovery from acute kidney injury.

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عنوان ژورنال:
  • Journal of the American Society of Nephrology : JASN

دوره 19 10  شماره 

صفحات  -

تاریخ انتشار 2008